Yvonne Edwards
Contact Information: YEdwards@med.miami.edu Assistant: Dori McLean 1501 NW 10th Ave. Miami, FL 33136 ph: 305-243-3976 fax: 305-243-2396 Yvonne Edwards Ph.D., is Research Assistant Professor at the Dr John T. MacDonald Department of Human Genetics, School of Medicine, University of Miami. Dr. Yvonne Edwards has over twenty years experience in the field of Computational Molecular Biology and Bioinformatics. Her research interests are in next generation data analysis, large-scale genome sequencing, assembly and functional annotation, gene prioritization strategies, stem cell informatics, gene expression regulation and structural genomics. She is also Director of Bioinformatics, John P. Hussman Institute for Human Genomics. As Director of Bioinformatics, she is responsible for Information Technology, Bioinformatics and Advanced Systems Integration for Medical Genomics and Laboratory Cores. 1: Edwards YJ, Lobley AE, Pentony MM, Jones DT. (2009) Insights into the regulation of ntrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol. 10(5):R50. 2: Edwards YJ, Bryson K, Jones DT. (2008) A meta-analysis of microarray gene expression in mouse stem cells: redefining stemness. PLoS One. 3(7):e2712. 3: Ikeda D, Ono Y, Snell P, Edwards YJ, Elgar G, Watabe S. (2007) Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis. Physiol Genomics. 32(1):1-15. 4: Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, Vavouri T, Smith SF, North P, Callaway H, Kelly K, Walter K, Abnizova I, Gilks W, Edwards YJ, Cooke JE,Elgar G. (2005) Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol. 3(1):e7. 6: Cottage A, Mullan L, Portela MB, Hellen E, Carver T, Patel S, Vavouri T, Elgar G, Edwards YJ. (2004) Molecular characterisation of the SAND protein family: a study based on comparative genomics, structural bioinformatics and phylogeny. Cell Mol Biol Lett. 9(4A):739-53. 7: Halling-Brown M, Sansom C, Moss DS, Elgar G, Edwards YJ. (2004) A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes. Nucleic Acids Res.32(8):2618-22. . 8: Clark MS, Edwards YJ, Peterson D, Clifton SW, Thompson AJ, Sasaki M, Suzuki Y, Kikuchi K, Watabe S, Kawakami K, Sugano S, Elgar G, Johnson SL (2003). Fugu ESTs: new resources for transcription analysis and genome annotation. Genome Res 13(12):2747-53. 9: Cottage AJ, Edwards YJ, Elgar G.(2003) AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals. Mamm Genome. 14(8):514-25. 10: Edwards YJ, Carver TJ, Vavouri T, Frith M, Bishop MJ, Elgar G. (2003) Theatre: A software tool for detailed comparative analysis and visualization of genomic sequence. 11: Edwards YJ, Cottage A. (2003) Bioinformatics methods to predict protein structure and function. A practical approach. Mol Biotechnol;23(2):139-66. 12: Sambrook JG, Russell R, Umrania Y, Edwards YJ, Campbell RD, Elgar G, Clark MS. (2002) Fugu orthologues of human major histocompatibility complex genes: a genome survey. Immunogenetics.54(6):367-80. 13: Aparicio S, Chapman J, Stupka E, Putnam N, Chia JM, Dehal P, Christoffels A, Rash S, Hoon S, Smit A, Gelpke MD, Roach J, Oh T, Ho IY, Wong M, Detter C, Verhoef F, Predki P, Tay A, Lucas S, Richardson P, Smith SF, Clark MS, EdwardsYJ, Doggett N, Zharkikh A, Tavtigian SV, Pruss D, Barnstead M, Evans C, Baden H, Powell J, Glusman G, Rowen L, Hood L, Tan YH, Elgar G, Hawkins T, Venkatesh B, Rokhsar D, Brenner S. (2002) Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science 23;(5585):1301-10. 14: Perkins SJ, Hinshelwood J, Edwards YJ, Jenkins PV. (1999) Structural and functional modelling of von Willebrand factor type A domains in complement and coagulation. Biochem Soc Trans. 27(6):815-20. 15: Hinshelwood J, Spencer DI, Edwards YJ, Perkins SJ. (1999) Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: implications for the activity of factor B. J Mol Biol. 294(2):587-99. 16: Elgar G, Clark MS, Meek S, Smith S, Warner S, Edwards YJ, Bouchireb N, Cottage A, Yeo GS, Umrania Y, Williams G, Brenner S.(1999) Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning. Genome Res. 9(10):960-71. 17: Clark MS, Edwards YJ, McQueen HA, Meek SE, Smith S, Umrania Y, Warner S, Williams G, Elgar G.(1999) Sequence scanning chicken cosmids: a methodology for genome screening. Gene. 227(2):223-30. 18: Edwards YJ, Elgar G, Clark MS, Bishop MJ. (1998) The identification and characterization of microsatellites in the compact genome of the Japanese pufferfish, Fugu rubripes: perspectives in functional and comparative genomic analyses. J Mol Biol. 278(4):843-54. 19: Edwards YJ, Perkins SJ. (1996) Assessment of protein fold predictions from sequence information: the predicted alpha/beta doubly wound fold of the von Willebrand factor type A domain is similar to its crystal structure. J Mol Biol. 260(2):277-85. 20: Edwards YJ, Perkins SJ. (1995) The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted beta-sheet flanked by alpha-helices found in human ras-p21. FEBS Lett. 358(3):283-6. |