Jacob L. McCauley


mccauley_Jacob_site.jpgJacob L. McCauley, PhD, is an Assistant Professor within the Dr. John T. Macdonald Foundation Department of Human Genetics. Dr. McCauley is a genetic epidemiologist whose primary interest is to improve the understanding of human disease through disease gene discovery, genomics, and in-depth examination of environmental factors that influence disease outcome. His research focuses on the use of molecular techniques, bioinformatics, and statistical methods to identify genetic variation and to characterize its role in disease susceptibility within a variety of neurological diseases. Dr. McCauley has been involved in studying a variety of neurological diseases including autism, Alzheimer disease, Parkinson disease, and multiple sclerosis.


jmccauley@med.miami.edu
Assistant Professor
Miami Institute for Human Genomics
University of Miami, Miller School of Medicine
1120 NW 14th Street, CRB-828 Miami, Florida 33136
(305) 243-4578 (office)
(305) 243-2396 (fax)

Selected Publications:
  1. Nurmi EL, Amin T, Olson LM, Jacobs MM, McCauley JL, Lam AY, Organ EL, Folstein SE, Haines JL and Sutcliffe JS. (2003) Dense linkage disequilibrium mapping in the 15q11-q13 maternal expression domain yields evidence for association in autism. Mol Psychiatry, 8(6): 624-34.
  2. McCauley JL, Dowd M, Olson LM, Amin T, Blakely RD, Folstein SE, Haines JL and Sutcliffe JS. (2004) Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. Am J Med Genet, 127B: 104-112.
  3. McCauley JL, Olson LM, Amin T, Organ EL, Folstein SE, Haines JL and Sutcliffe JS. (2004) A linkage disequilibrium map of the 1-Mb 15q12 GABAA receptor subunit cluster and association to autism. Am J Med Genet, 131(B): 55-59.
  4. Skaar D, Shao Y, Haines JL, Stenger JE, Jaworski J, Martin ER, DeLong R, Moore JH, McCauley JL, Sutcliffe JS, Ashley-Koch AE, Cuccaro ML, Folstein SE, Gilbert JR, Pericak-Vance MA. (2005). Analysis of the RELN gene as a genetic risk factor for autistic disorder. Mol Psychiatry, 10(6): 563-71.
  5. McCauley JL, Li C, Jiang L, Olson LM, Crockett G, Gainer K, Folstein SE, Haines JL and Sutcliffe JS. (2005) Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC Med Genet, 6: 1.
  6. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, and Blakely RD. (2005) Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proc Natl Acad Sci USA, 102(32) 11545-50.
  7. Sutcliffe JS, Delahanty RJ, Prasad HC, McCauley JL, Han Q, Jiang L, Li C, Folstein SE, Blakely RD. (2005) Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors. Am J Hum Genet, 77(2): 265-79.
  8. Hahs DW, McCauley JL, Crunk AE, McFarland LL, Gaskell PC, Jiang L, Slifer SH, Vance JM, Scott WK, Welsh-Bohmer KA, Johnson SR, Jackson CE, Pericak-Vance MA, Haines JL. (2006) A genome-wide linkage analysis of dementia in the Amish. Am J Med Genet, 141(B): 160-166.
  9. McCauley JL, Hahs DW, Jiang L, Scott WK, Welsh-Bohmer KA, Jackson CE, Vance JM, Pericak-Vance MA, Haines JL. (2006) Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish. BMC Med Genet, 7: 19.
  10. Rabionet R, McCauley JL, Jawarski JM, Ashley-Kock AE, Martin ER, Sutcliffe JS, Haines JL, DeLong GR, Abramson RK, Wright HH, Cuccaro ML, Gilbert JR, Pericak-Vance MA.(2006) Lack of association between autism and SLC25A12. Am J Psychiatry, 163(5):929-31.
  11. McCauley JL, Kenealy SJ, Margulies EH, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Pericak-Vance MA, Haines JL, Mortlock DP. (2007) SNPs in Multi-Species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. BMC Genomics, 8: 266.
  12. Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL. (2007) for the Multiple Sclerosis Genetics Group: Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet. 2007 Sep;
    13. 9(9):1083-91
  13. The International Multiple Sclerosis Genetics Consortium. Hafler DA, Compston DA, Sawcer SJ, Lander ES, Daly MJ, De Jager PL, I.W. de Bakker P, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL. (2007) Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study. N Engl J Med. 2007 Aug 30; 57(9):851-62.
  14. Lee S, Murdock D, McCauley JL, Bradford Y, Crunk A, McFarland L, Jiang L, Wang T, Schnetz-Boutand N, Haines JL: A Genome-wide Scan in an Amish Pedigree with Parkinsonism Ann Hum Genet. 2008 May 26. [Epub ahead of print] (2008).
  15. The International Multiple Sclerosis Genetics Consortium. Refining novel associations in multiple sclerosis. Lancet Neurol, 2008 Jul;7(7):567-9