Eden R. Martin


Martin_Eden-web.jpgEden R. Martin, PhD, is Director of the Center for Genetic Epidemiology and Statistical Genetics at the MIHG and Professor of Human Genetics. Dr. Martin is a statistical geneticist whose interest is in mapping genes for complex diseases using linkage disequilibrium methods. Her research has focused on extensions of the transmission/disequilibrium test (TDT) for linkage and association studies in nuclear families. She developed the Pedigree Disequilibrium Test (PDT) for analysis of linkage disequilibrium in general pedigrees, and recently developed the APL test for haplotype analysis. In addition to methodological developments, Dr. Martin is involved in studies of several disorders, including Alzheimer disease, Parkinson disease, and autism.


Contact Information
emartin1@med.miami.edu
Assistant: Lili Tewes
Miami Institute for Human Genomics
1120 NW 14th Street
Miami, FL 33136
ph: 305-243-5391
fax: 305-243-2396

Selected Publications

  1. Kaplan NL, Martin ER, Weir BS. (1997) Power studies for the transmission/disequilibrium tests with multiple alleles. Am J Hum Genet 60:691-702.
  2. Rogaeva EA, Premkumar S, Grubber J, Serneels L, Scott WK, Kawarai T, Yu G, Hill D, Aboudonia S, Martin ER, Claxton C, Song Y, Roberge B, Saunders A, Roses AD, Schmechel D, Crane A, Small G, Conneally PM, Haines JL, VanLeuven F, St. George-Hyslop P, Farrer, LA, Pericak-Vance, MA. (1999) A comprehensive examination of an -2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. Nature Genetics 2(1):19-22.
  3. Martin ER, Menold MM, Wolpert CM, Bass MP, Donnelly SL, Ravan SA, Zimmerman A, Gilbert JR, Vance JM, Maddox LO, Wright H, Abramson RK, DeLong DR, Cuccaro ML, Pericak-Vance MA. (2000) Analysis of linkage disequilibrium in α-aminobutyric acid receptor subunit genes in Autistic Disorder. Am J Med Genet (Neuropsychiatric Genetics) 96:43-48.
  4. Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, Riley J, Finch KL, Stevens JF, Livak KJ, Slotterbeck BD, Slifer SH, Warren LL, Conneally PM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, Vance, J. (2000) SNPing away at complex diseases: Analysis of SNPs around APOE in Alzheimer disease. Am J Hum Genet 67:383-394.
  5. Martin ER, Bass MP, Kaplan NL. (2001) Correcting for a potential bias in the pedigree disequilibrium test. Am J Hum Genet 68:1065-1067.
  6. Martin ER, Scott WK, Nance NA, Watts RL, Hubble JP, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH, Goetz CG, Small GW, Masterman D, Mastaglia F, Laing NG, Stajich JM, Ribble RC, Booze MW, Rogala A, Hauser MA, Zhang F, Gibson RA, Middleton LT, Roses AD, Haines JL, Scott BL, Pericak-Vance MA, Vance JM. (2001) Association analysis of the tau gene with late-onset Parkinson disease: Association with intragenic single nucleotide polymorphisms. JAMA 286(18):2245-2250.
  7. Martin ER, Bass MP, Hauser ER, Kaplan NL. (2003) Accounting for linkage in family-based tests of association with missing parental genotypes. Am J Hum Genet. 73:1016-1026.
  8. Nicodemus KR, Stenger JE, Schmechel DE, Welsh-Bohmer KA, Saunders AM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA, Martin ER. (2004) Comprehensive Association Analysis of APOE Regulatory Region Polymorphisms in Alzheimer Disease. Neurogenetics 5(4): 201-208.
  9. Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, DeLong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA (2005) Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet 77:377-388.
  10. Martin ER, Bronson PG, Li Y-J, Wall N, Chung R-H, Schmechel DE, Small G, Xu P-T, Bartlett J, Schnetz-Boutaud N, Haines JL, Gilbert JR, Pericak-Vance MA (2005) The α -T catenin gene (VR22) is associated with Alzheimer Disease and interacts with APOE. J Med Genet 42(10):787-92.
  11. Martin ER, Ritchie MD, Hahn L, Kang S, and Moore JH (2006) A novel method to identify gene-gene effects in nuclear families: the MDR-PDT. Genet.Epidemiol 30 (2):111-123.
  12. Chung, RH; Hauser, ER; Martin, ER. Interpretation of simultaneous linkage and family-based association tests in genome screens. Genet Epidemiol. 2007 Feb;31(2):134-42
  13. Hancock DB, Martin ER, Li YJ, Scott WK. Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations. Genet Epidemiol. 2007 Dec; 31(8):883-93.
  14. Schmidt S, Schmidt MA, Qin X, Martin ER, Hauser ER. Increased Efficiency of Case-Control Association Analysis by Using Allele-Sharing and Covariate Information. Hum Hered. 2008; 65(3):154-65.