Eden R. Martin


Martin_Eden-web.jpg Contact Information
emartin1@med.miami.edu
Assistant: Lili Tewes
1501 NW 10 Ave.
Miami, FL 33136
ph: 305-243-5391
fax: 305-243-2396







Eden R. Martin, Ph.D., is Director of the Center for Genetic Epidemiology and Statistical Genetics at the HIHG and Professor of Human Genetics. Dr. Martin is a statistical geneticist whose interest is in mapping genes for complex diseases using linkage disequilibrium methods. Her research has focused on developing extensions of transmission/disequilibrium test (TDT) for linkage and association studies in nuclear families, such as the Pedigree Disequilibrium Test (PDT) for analysis of linkage disequilibrium in general pedigrees, and the APL test for haplotype analysis. She has also developed a suite of analysis programs for the X chromosome and developed methods for testing gene-gene interaction. In addition to methodological developments, Dr. Martin is involved in studies of several disorders, including Alzheimer disease, Parkinson disease, and autism.

Selected Publications


  1. Rogaeva EA, Premkumar S, Grubber J, Serneels L, Scott WK, Kawarai T, Yu G, Hill D, Aboudonia S, Martin ER, Claxton C, Song Y, Roberge B, Saunders A, Roses AD, Schmechel D, Crane A, Small G, Conneally PM, Haines JL, VanLeuven F, St. George-Hyslop P, Farrer, LA, Pericak-Vance, MA. (1999) A comprehensive examination of an α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. Nature Genetics 2(1):19-22.


  2. Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, Riley J, Finch KL, Stevens JF, Livak KJ, Slotterbeck BD, Slifer SH, Warren LL, Conneally PM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, Vance, J. (2000) SNPing away at complex diseases: Analysis of SNPs around APOE in Alzheimer disease. Am J Hum Genet 67:383-394.


  3. Martin ER, Monks SA, Warren LL, Kaplan, N. (2000) A test for linkage and association in general pedigrees: The pedigree disequilibrium test (PDT). Am J Hum Genet 67:146-154.


  4. Martin ER, Bass MP, Kaplan NL. (2001) Correcting for a potential bias in the pedigree disequilibrium test. Am J Hum Genet 68:1065-1067.


  5. Martin ER, Scott WK, Nance NA, Watts RL, Hubble JP, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH, Goetz CG, Small GW, Masterman D, Mastaglia F, Laing NG, Stajich JM, Ribble RC, Booze MW, Rogala A, Hauser MA, Zhang F, Gibson RA, Middleton LT, Roses AD, Haines JL, Scott BL, Pericak-Vance MA, Vance JM. (2001) Association analysis of the tau gene with late-onset Parkinson disease: Association with intragenic single nucleotide polymorphisms. JAMA 286(18):2245-2250.


  6. Martin ER, Bass MP, Hauser ER, Kaplan NL. (2003) Accounting for linkage in family-based tests of association with missing parental genotypes. Am J Hum Genet. 73:1016-1026.


  7. Nicodemus KR, Stenger JE, Schmechel DE, Welsh-Bohmer KA, Saunders AM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA, Martin ER. (2004) Comprehensive Association Analysis of APOE Regulatory Region Polymorphisms in Alzheimer Disease. Neurogenetics 5(4): 201-208.


  8. Van der Walt JM, Noureddine MA, Kittappa R, Hauser MA, Scott WK, McKay R, Zhang F, Stajich JM, Fujiwara K, Hauser MA, Scott BL, Pericak-Vance MA, Vance JM, Martine ER. (2004) Fibroblast Growth Factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. Am J Hum Genet 74(6): 1121-7.


  9. Martin ER, Bronson PG, Li Y-J, Wall N, Chung R-H, Schmechel DE, Small G, Xu P-T, Bartlett J, Schnetz-Boutaud N, Haines JL, Gilbert JR, Pericak-Vance MA (2005) The α-T (VR22) is associated with Alzheimer Disease and interacts with APOE. J Med Genet 42(10):787-92.


  10. Martin ER, Ritchie MD, Hahn L, Kang S, and Moore JH (2006) A novel method to identify gene-gene effects in nuclear families: the MDR-PDT. Genet.Epidemiol 30 (2):111-123.


  11. Chung, RH; Hauser, ER; Martin, ER. Interpretation of simultaneous linkage and family-based association tests in genome screens. Genet Epidemiol. 2007 Feb;31(2):134-42.


  12. Hancock DB, Martin ER, Li YJ, Scott WK. Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations. Genet Epidemiol. 2007 Dec; 31(8):883-93.


  13. Gao X, Scott WK, Wang G, Mayhew G, Li Y-J, Vance JM, Martin ER. (2008) Gene-gene interaction between FGF20 and MAOB in Parkinson Disease. Annals of Hum Genet. Mar; 72 (Pt2); 157-62.


  14. Martin ER, Schmidt MA. (2008) The Future is Now. Will the real disease gene please stand up? Human Heredity; 66 (2):127-35.


  15. Beecham GW, Martin ER, Li Y-J, Carney RM, Slifer MA, Gilbert JR, Haines JL, Pericak-Vance, MA. (2009) Genome-wide association implicates a chromosome 12 risk locus for Late-Onset Alzheimer disease. Am J Hum Genet. Jan; 84 (1):35-43.