William K. Scott


scott_9581_web resize.jpg Contact information:
bscott@med.miami.edu
Assistant: Dori McLean
1501 NW 10th Ave.
Miami, FL 33136
ph: 305-243-8779
fax: 305.243.2396







William K. Scott, Ph.D., is Professor of Human Genetics and Vice Chair for Education and Training in the Dr. John T. Macdonald Foundation Department of Human Genetics. Dr. Scott is a genetic epidemiologist interested in the influence of genetic and environmental factors on infectious diseases and complex traits associated with aging. He directs studies of genetic susceptibility to tuberculosis and of longevity and successful aging in the Amish communities of Indiana and Ohio. Dr. Scott is currently involved in studies of environmental risk factors and gene-environment interactions in aging related traits such as Parkinson disease and age-related macular degeneration.

Selected Publications

  1. Scott WK, Pericak-Vance MA, Haines JL. Genetic analysis of complex diseases. Science 1997;275:1327.


  2. Scott WK, Stajich JM, Yamaoka LH, Speer MC, Vance JM, Roses AD, Pericak-Vance MA. The genetic complexity of Parkinson disease. Science 1997; 277:387-88.


  3. Scott WK, Nance MA, Watts RL, Hubble JP, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH Jr, Goetz CG, Small GW, Masterman D, Mastaglia F, Laing NG, Stajich JM, Slotterbeck B, Booze MW, Ribble RC, Rampersaud E, West SG, Gibson RA, Middleton LT, Roses AD, Haines JL, Scott BL, Vance JM, Pericak-Vance MA. Complete genomic screen in Parkinson disease: Evidence for multiple genes. JAMA 2001; 286(18): 2239-2244.


  4. Scott WK, Hauser ER, Schmechel DE, Welsh-Bohmer KA, Small GW, Roses AD, Saunders AM, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA. Ordered subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. American Journal of Human Genetics 2003; 73:1041-1051.


  5. Scott WK, Zhang F, Stajich JM, Scott BL, Stacy MA, Vance JM. Family-based case-control study of cigarette smoking and Parkinson disease. Neurology 2005; 64(3):442-7.


  6. Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, Spencer KL, Kwan SY, Noureddine M, Gilbert JR, Schnetz-Boutaud N, Agarwal A, Postel EA, Pericak-Vance MA. Complement factor H variant increases the risk of age-related macular degeneration. Science 2005; 308:419-421.


  7. Hancock DB, Martin ER, Fujiwara K, Stacy MA, Scott BL, Stajich JM, Jewett R, Li YJ, Michael A, Hauser MA, Vance JM, Scott WK. NOS2A and the modulating effect of cigarette smoking in Parkinson disease. Annals of Neurology 2006 Sep;60(3):366-73.


  8. Scott WK, Schmidt S, Hauser MA, Gallins P, Schnetz-Boutaud N, Spencer KL, Gilbert JR, Agarwal A, Postel EA, Haines JL, Pericak-Vance MA. Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration. Ophthalmology 2007 June; 114(6):1151-6. Epub 2007 Jan 19.


  9. Hancock DB, Martin ER, Stajich JM, Jewett R, Stacy MA, Scott BL, Vance JM, Scott WK. Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson's disease. Archives of Neurology. 2007 Apr;64(4):576-80.


  10. Hancock DB, Martin ER, LI YJ, Scott, WK. Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations. Genet Epidemiology 2007 Dec;31(8):883-93.


  11. Hancock DB, Martin ER, Mayhew GM, Stajich JM, Jewett R, Stacy MA, Scott BL, Vance JM, Scott WK. Pesticide exposure and risk of Parkinson's disease: a family-based case-control study. BMC Neurology 2008; 8:6.