Center for Models of Human Disease

Center Director: TBN

The Center for Models of Human Disease is an integrated, multi-organism center to rapidly and simultaneously evaluate the biology of previously identified susceptibility genes as well as Mendelian genes for human disease.  These models can be used to identify disease mechanisms, and to create genetic and biology-based models that can be used as targets for therapeutic screening by the research community.  To move genetic findings into translation and eventually to the patients, they need to be evaluated rapidly and specific mechanisms must be identified and translated into biological models.  Different methods and organisms all have advantages and strengths, many of which will not be fully realized for a gene until it is studied.  By establishing a group of interacting individuals, each an expert in using a specific organism or technique for modeling studies, we will maximize the potential of each model and speed the study of these important biological variables.