Center for Genome TechnologyCenter Director: John R. Gilbert, Ph.D. Associate Director: Dale J. Hedges , Ph.D. Dr. Gilbert research interests encompass the molecular genetics of autistic disorder, Alzheimer disease, Essential tremor, Genetics of Infectious disease, and other complex genetic disorders. As a molecular biologist, his expertise is in complex genetic disorders including, molecular genetics, gene analysis and characterization, RNA transcription and control, mutation analysis, and animal models of human disorders. The role of the CGT is to identify, develop, and maintain cutting edge technologies and apply state-of-the-art methods in genomics, proteomics and ultimately metabolomics to the localization, identification and characterization of human disease genes and disease processes. In addition, through the development of academic and industrial resources and collaboration at local, regional, national and international levels, the CGT will actively be engaged in and lead in the identification, development, and testing of new cutting edge research methods, technologies, and applications in the biology of human disease. The ultimate aim of the CGT is to provide the necessary technical tools and methodological "know-how" to enable a complete systems approach to the study and analysis of human disorders. Such studies include disease gene localization (genotyping), the effects of DNA copy number variation, gene expression analysis, modern ultra-high-throughput next generation (NGS) sequencing and re-sequencing, analysis of the effects of epigenetic abnormalities, the study of protein expression in disease states and animal models, as well as protein-protein interactions, and finally the measurement of the metabolic outcome of both the disease state and treatment response. The CGT employs faculty researchers, laboratory directors and personnel all with expertise in genomic and proteomic methods and technology. The CGT provides cutting edge technology and collaborative expertise to help establish new research collaborations and goals within the University and its departments. The Associate Director of the CGT focuses on establishing and overseeing external collaborative research and activities, assisting other University researchers in developing research projects involving CGT resources, and assisting in the general administration and oversight of the CGT. The core resources available through the CGT are: Genotyping Core, Sequencing Core, Microarray, Copy Number Variant and Gene Expression Core, and the Technology Development Core. Links to the core resources are listed below: |