MDR-Phenomics
MDR-Phenomics aims to detect gene-gene interaction in the pedigree data. Reference:

Mei H, Cuccaro ML, Martin ER. Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables. Am J Hum Genet. 2007 Dec; 81(6):1251-61

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